The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
MDM2 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. 11 alternatively spliced human isoforms have been reported. MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase, which belongs to the MDM2/MDM4 family. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. It Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Overexpression or amplification of this locus is detected in a variety of different cancers. MDM2 is widely expressed in the colon, bone marrow, and other tissues. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation.
Zhuo X, Ye H, Li Q, Xiang Z, Zhang X. Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals. Langevin. S, ed. Medicine. 2016;95(9):e2948.