LFA-1 cDNA ORF Clone, Human, untagged

LFA-1 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
3513 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence except for the point mutation 2928 A/G not causing the amino acid variation.
製品の特徴
Full length Clone DNA of Human integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide).
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
制限部位
KpnI + XbaI (6.1kb + 3.51kb)
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

LFA-1 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

LFA-1 cDNA ORF Clone, Human, untagged: 検証済の画像

LFA-1 cDNA ORF Clone, Human, untagged: 別名

CD11A cDNA ORF Clone, Human; LFA-1 cDNA ORF Clone, Human; LFA1A cDNA ORF Clone, Human

LFA-1 背景情報

ITGAL (Integrin Subunit Alpha L) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. ITGAL encodes the integrin alpha L chain, which belongs to the integrin alpha chain family. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. Hypomethylation of regions flanking the ITGAL promoter may increase CD11a expression and suggest that age-dependent hypomethylation of promoters lacking CpG islands, perhaps due to decreased DNA methyltransferase expression, may be one mechanism contributing to increased T cell gene expression with aging. Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency.
完全な名称
integrin subunit alpha L
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    Actin Dynamics Signaling Pathway
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    AKT Signaling Pathway
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    G Protein-coupled Receptors Signaling
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
  • Autophagy Pathway
    Autophagy Pathway
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