Gremlin 1/GREM1 cDNA ORF Clone in Cloning Vector, Human

Gremlin 1/GREM1 cDNA ORF Clone in Cloning Vector, Human: 製品情報

NCBI 参考シーケンス番号
555 bp
Identical with the Gene Bank Ref. ID sequence except for the point mutation 207 C/G not causing the amino acid variation.
Full length Clone DNA of Human gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis).
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

Gremlin 1/GREM1 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Gremlin 1/GREM1 cDNA ORF Clone in Cloning Vector, Human: 別名

C15DUPq cDNA ORF Clone, Human; CKTSF1B1 cDNA ORF Clone, Human; CRAC1 cDNA ORF Clone, Human; CRCS4 cDNA ORF Clone, Human; DAND2 cDNA ORF Clone, Human; DRM cDNA ORF Clone, Human; DUP15q cDNA ORF Clone, Human; GREMLIN cDNA ORF Clone, Human; HMPS cDNA ORF Clone, Human; HMPS1 cDNA ORF Clone, Human; IHG-2 cDNA ORF Clone, Human; MPSH cDNA ORF Clone, Human; PIG2 cDNA ORF Clone, Human

Gremlin 1/GREM1 背景情報

GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon.
gremlin 1, DAN family BMP antagonist
  • Dimitrov BI, et al. (2010) Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. J Med Genet. 47(8):569-74.
  • Heron M, et al. (2011) Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. Tissue Antigens. 77(2):112-7.
  • van Vlodrop IJ, et al. (2010) Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol. 176(2):575-84.
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