ER alpha cDNA ORF Clone in Cloning Vector, Human

ER alpha cDNA ORF Clone in Cloning Vector, Human: 製品情報

NCBI 参考シーケンス番号
1788 bp
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human estrogen receptor 1.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.

ER alpha cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ER alpha cDNA ORF Clone in Cloning Vector, Human: 別名

ER cDNA ORF Clone, Human; Era cDNA ORF Clone, Human; ESR cDNA ORF Clone, Human; ESRA cDNA ORF Clone, Human; ESTRR cDNA ORF Clone, Human; NR3A1 cDNA ORF Clone, Human

ER alpha 背景情報

An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-301a-3p and suggest that miR-301a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture.
estrogen receptor 1
Related Pathways
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
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