ER alpha cDNA ORF Clone, Human, C-Myc tag

ER alpha cDNA ORF Clone, Human, C-Myc tag: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
1788 bp
製品の特徴
Full length Clone DNA of Human estrogen receptor 1 with C terminal Myc tag.
プラスミド
プロモーター
Enhanced CMV promoter
ベクター
タグシーケンス
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
シークエンシングプライマー
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Kanamycin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ER alpha cDNA ORF Clone, Human, C-Myc tag: 別名

ER cDNA ORF Clone, Human; Era cDNA ORF Clone, Human; ESR cDNA ORF Clone, Human; ESRA cDNA ORF Clone, Human; ESTRR cDNA ORF Clone, Human; NR3A1 cDNA ORF Clone, Human

ER alpha 背景情報

An ESR1 gene mutation, which encodes for the estrogen receptor (ER) protein, is one of the potential mechanisms of therapy resistance. The ESR1 mutations result in conformational changes in the ER leading to subsequent estrogen-independent transcriptional activity. The mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Estrogen receptor alpha (ERalpha) is one of the estrogen hormone-activated transcription factors, which regulates a large number of genes and is involved in the mammary gland development. Expression of ERalpha is considered to be a good indicator for endocrine therapy and breast cancer survival. Loss of ERalpha in breast cancer patients indicates invasiveness and poor prognosis. ESR1 as a direct target of miR-301a-3p and suggest that miR-301a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer. Polymorphisms of the estrogen receptor gene alpha (ESR1) are consistently been associated with bone mineral density (BMD) and fracture.
完全な名称
estrogen receptor 1
Related Pathways
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
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