The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
CR1/CD35 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Complement receptor type 1 (CR1) is a multi-modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor for complement-opsonins C3b and C4b and specifically interacts through pairs of CCP modules located in LHR A, B, and C. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. The CR1 gene was shown to be involved in Alzheimer's disease (AD).
Sandri TL, et al. (2018) Human complement receptor type 1 (cr1) protein levels and genetic variants in chronic chagas disease. Sci Rep 8 (1): 526.
Panda AK, et al. (2016) Cr1 exon variants are associated with lowered cr1 expression and increased susceptibility to sle in a plasmodium falciparum endemic population. Lupus Sci Med 3 (1): e000145.
Mahmoudi R, et al. (2018) Inherited and acquired decrease in complement receptor 1 (cr1) density on red blood cells associated with high levels of soluble cr1 in alzheimer's disease. Int J Mol Sci 19 (8): 2175.
Jacquet M, et al. (2018) C1q and mannose-binding lectin interact with cr1 in the same region on ccp24-25 modules. Front Immunol 9 453.