CR1/CD35 cDNA ORF Clone, Human, untagged

CR1/CD35 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
6120 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence.
製品の特徴
Full length Clone DNA of Human complement component (3b/4b) receptor 1 (Knops blood group)
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
制限部位
KpnI + NotI(6.1kb+6.12kb)
シークエンシングプライマー
T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

CR1/CD35 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CR1/CD35に関するより多くの情報

Entrez Gene ID

CR1/CD35 cDNA ORF Clone, Human, untagged: 検証済の画像

CR1/CD35 cDNA ORF Clone, Human, untagged: 別名

C3BR cDNA ORF Clone, Human; C4BR cDNA ORF Clone, Human; CD35 cDNA ORF Clone, Human; KN cDNA ORF Clone, Human; RP11-57I17.1 cDNA ORF Clone, Human

CR1/CD35 背景情報

Complement receptor type 1 (CR1) is a multi-modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor for complement-opsonins C3b and C4b and specifically interacts through pairs of CCP modules located in LHR A, B, and C. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. The CR1 gene was shown to be involved in Alzheimer's disease (AD).
完全な名称
complement component 3b/4b receptor 1 (Knops blood group)
参考文献
  • Sandri TL, et al. (2018) Human complement receptor type 1 (cr1) protein levels and genetic variants in chronic chagas disease. Sci Rep 8 (1): 526.
  • Panda AK, et al. (2016) Cr1 exon variants are associated with lowered cr1 expression and increased susceptibility to sle in a plasmodium falciparum endemic population. Lupus Sci Med 3 (1): e000145.
  • Mahmoudi R, et al. (2018) Inherited and acquired decrease in complement receptor 1 (cr1) density on red blood cells associated with high levels of soluble cr1 in alzheimer's disease. Int J Mol Sci 19 (8): 2175.
  • Jacquet M, et al. (2018) C1q and mannose-binding lectin interact with cr1 in the same region on ccp24-25 modules. Front Immunol 9 453.
カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください U.S.A.