Anti-CD8 alpha Antibody (APC)

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Anti-CD8 alpha Antibody (APC) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-CD8 alpha Antibody (APC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Ferret
特異性
Ferret CD8 alpha
免疫原
Recombinant Ferret CD8a / Lyt2 protein (Catalog#60001-F08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Ferret CD8a / Lyt2 (rF CD8a / Lyt2; Catalog#60001-F08H; ABS50091.1; Met1-Glu186) and conjugated with APC under optimum conditions, the unreacted APC was removed.
ソース
Monoclonal Rabbit IgG Clone #082
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
APC
濃度
5 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD8 alpha Antibody (APC) (Rabbit Monoclonal 抗体) の画像

Analysis of Ferret CD8A expression on ferret splenocytes. Ferret splenocytes were stained with PerCP-conjugated rabbit anti-Ferret CD8A. The histogram were derived from the gated events based on light scattering characteristics of viable cells.

CD8 alpha 背景情報

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
完全な名称
CD8a molecule
参考文献
    References Devine, L. et al., 2000, J Immunol. 164 (2): 833-8. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.
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