CD3D cDNA Clone: Expression and Clone Vector / Plasmid

CD3D cDNA / Gene Overview

CD3D gene / cDNA is a protein-coding gene which located on 11q23.3. The CD3D gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.154 organisms have orthologs with human gene CD3D.

CD3D cDNA / Gene Function

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

CD3D cDNA / Gene Sequence

LOCUS
LOCUS NM_000732 771 bp mRNA linear PRI 23-JUN-2018
DEFINITION
Homo sapiens CD3d molecule (CD3D), transcript variant 1, mRNA.
ACCESSION
NM_000732
VERSION
NM_000732.4

This sequence information is just for reference only.

CD3D Family & Reagents

Gene family

CD3D Gene family reagents (CD molecules)

Approved Symbol Reagent list
FCRL2
F11R
BMPR1B
ADGRE5
NECTIN2
ART4
TNFRSF17
SPN
KIR2DL1
IL18RAP
Approved Symbol Reagent list
ICAM1
LILRA3
LILRB5
CD320
LAMP1
CD74
SLAMF8
PTPRC
CD53
CR2

CD3D cDNA / Gene Expression

Biased expression in lymph node (RPKM 30.2), appendix (RPKM 14.7) and 9 other tissues