CD122 / IL2RB cDNA Clone: Expression and Clone Vector / Plasmid

CD122 / IL2RB cDNA / Gene Overview

IL2RB gene / cDNA is a protein-coding gene which located on 22q12.3. The IL2RB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.209 organisms have orthologs with human gene IL2RB.

CD122 / IL2RB cDNA / Gene Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

CD122 / IL2RB cDNA / Gene Sequence

LOCUS
LOCUS NM_000878 4118 bp mRNA linear PRI 30-JUN-2018
DEFINITION
Homo sapiens interleukin 2 receptor subunit beta (IL2RB), transcript variant 1, mRNA.
ACCESSION
NM_000878
VERSION
NM_000878.4

This sequence information is just for reference only.

CD122 / IL2RB Family & Reagents

CD122 / IL2RB Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD70
JAM2
CSF2RB
IL12RB1
IL17RA
ADAM8
TNFRSF21
CD27
ICAM3
LY9
Approved Symbol Reagent list
CD24
CD180
MS4A1
NGFR
TNFRSF8
CD79B
TNFRSF10A
BST1
TNFRSF12A
CD37

CD122 / IL2RB Gene family reagents (Interleukin receptors)

Approved Symbol Reagent list
IL3Ra
IL10RB
IL18RAP
IL13Ra2
IL1R2
IL6ST
IL17RA
IL11RA
IL18R1
IL12RB2
Approved Symbol Reagent list
IL1RN
IL6R
IL4R
IL1R1
IL21R
IL9R
IL1RAP
IL17RB
IL1RAPL1
IL13Ra1

CD122 / IL2RB cDNA / Gene Alias

  • CD122

CD122 / IL2RB cDNA / Gene Expression

Broad expression in spleen (RPKM 33.2), lymph node (RPKM 19.6) and 14 other tissues