IL2RB gene / cDNA is a protein-coding gene which located on 22q12.3. The IL2RB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.209 organisms have orthologs with human gene IL2RB.
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]
CD122 / IL2RB cDNA / Gene Sequence
LOCUS NM_000878 4118 bp mRNA linear PRI 30-JUN-2018