The CD antigens /Cluster of Differentiation nomenclature was established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), which was held in Paris in 1982.
The HLDA Workshops provide a mechanism to allocate CD nomenclature through engaging in inter-laboratory studies. HLDA Workshops is a international organization that studies of leucocyte surface molecules have been organised. Before the HLDA Workshop was set up, monoclonal antibodies against leucocyte antigens were relatively new and large numbers of new antibodies were being produced. It was difficult to know which antibodies were against the same molecules.In the first HLDA Workshop, evaluated and compared many of these antigens, This way has provided independent validation of antibody specificity and usability, and has underpinned the confident use of these reagents in research, diagnosis and therapy. Today, the HLDA Workshop meeting has been held 10 times and has over 370 CD markers have been identified.
The CD antigens is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. CD antigens can act in lot of ways, like as recepters or ligands in terms of physiology.As a siganl, CD antigens is usually initiated, altering the behavior of the cell. Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD antibodies are used widely for research, immunotherary , tumor and drug target.