Wnt7a Antibodies, cDNA Clones Research Reagents

WNT7A (Wnt Family Member 7A, also known as Wnt-7a), located on 3p25.1, is a Protein Coding gene. The gene produces a 39005 Da protein composed of 349 amino acids. WNT7A, an important ligand of Wnt/β-catenin signaling pathways, has a controversial role in tumor development. Loss of Wnt7a expression may contribute to the carcinogenesis and tumor progression of colorectal adenocarcinoma and maybe a new prognostic marker of colorectal adenocarcinoma. Diseases such as Fibular Aplasia Or Hypoplasia, Femoral Bowing, And Poly-, Syn-, And Oligodactyly are associated with WNT7A.

Wnt7a Antibody (2)

    Wnt7a cDNA Clone (26)

    NM_004625.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_009527.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    Wnt7a の背景知識

    Wnt7a, a 39Kd secreted glycoprotein composed of 349 amino acids, is a member of the Wnt family and has been reported to be involved in the carcinogenesis and progression of many types of human cancer. Wnt7a could be used as a potential diagnostic marker and target for gastric cancer (GC) management. Wnt7a is a known tumor suppressor gene in non-small cell lung cancer that regulates normal cellular proliferation and differentiation. Loss of Wnt7a expression may contribute to the carcinogenesis and tumor progression of colorectal adenocarcinoma and maybe a new prognostic marker of colorectal adenocarcinoma. WNT7A, an important ligand of Wnt/β-catenin signaling pathways, has a controversial role in tumor development.

    Wnt7a の参考文献

    • Wu DJ, et al. (2018) High expression of wnt7a predicts poor prognosis and promote tumor metastasis in pancreatic ductal adenocarcinoma. Sci Rep 8 (1): 15792.
    • Liu Y, et al. (2019) Wnt7a, frequently silenced by cpg methylation, inhibits tumor growth and metastasis via suppressing epithelial-mesenchymal transition in gastric cancer. J Cell Biochem 120 (10): 18142-18151.
    • Lan L, et al. (2019) Wnt7a overexpression inhibits growth and migration of hepatocellular carcinoma via the β-catenin independent pathway. Biomed Res Int 2019 3605950.
    • Jang SM, et al. (2018) Loss of wnt7a expression correlates with tumor progression and poor prognosis in colorectal carcinoma. Int J Clin Exp Pathol 11 (10): 4967-4976.

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