ULBP1 Proteins, Antibodies, cDNA Clones Research Reagents

ULBP1 (UL16 Binding Protein 1) is a protein coding gene located on human chromosome 6q25.1. ULBP1 is also known as N2DL-1, RAET1I and NKG2DL1. The human ULBP1 gene encodes a 27997 Da protein containing 244 amino acids. The ULBP1 protein is biasedly expressed in testis, lung and other tissues. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System. ULBP1 is related to peptide antigen binding and natural killer cell lectin-like receptor binding. RAET1L is an important paralog of ULBP1 gene.

ULBP1 Protein (3)

    ULBP1 Antibody (1)

      ULBP1 cDNA Clone (26)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      ULBP1 qPCR Primer (1)

      ULBP1 Lysate (2)

        ULBP1 の背景知識

        UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. ULBP1 is expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver and bone marrow, as well as some tumor cells. As an unconventional member of the MHC class I family, ULBP1 function in immune responses, especially in cancer and infectious diseases. Unlike other ULBP members, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.

        ULBP1 の参考文献

          1.  Rölle, A. et al., 2003, J Immunol. 171(2): 902-908.  

          2.  López-Soto, A. et al., 2006, J Biol Chem. 281(41): 30419-30430.      

          3.  Song, H. et al., 2006, Cell Immunol. 239(1): 22-30.  

          4.  Eisele, G. et al., 2006, Brain. 129 (9): 2416-2425.   

          5.  Romphruk, AV. et al., 2009, Immunogenetics. 61(9): 611-617. 

          6.  Sutherland, C.L. et. al., 2002, J. Immunol. 168: 671-679.

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