UBE2F Proteins, Antibodies, cDNA Clones Research Reagents

UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a protein coding gene located on human chromosome 2q37.3. UBE2F is also known as NCE2. The human UBE2F gene encodes a 21077 Da protein containing 185 amino acids. The UBE2F protein is ubiquitously expressed in bone marrow, thyroid and other tissues. Among its related pathways are Remodeling of Adherens Junctions and Innate Immune System. UBE2F is related to ligase activity and ubiquitin protein ligase activity. UBE2F-SCLY is an important paralog of UBE2F gene. UBE2F is associated with some diseases, such as Brachydactyly, Type E2.

UBE2F Protein (1)

    UBE2F Antibody (1)

      UBE2F cDNA Clone (32)

      NM_080678.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_026454.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_006245422.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      UBE2F の背景知識

      UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by a ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin-protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.

      UBE2F の参考文献

      • Sjoerd J L van Wijk, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol. 5: 317.
      • Nandi D, et al. (2006) The ubiquitin-proteasome system. Journal of biosciences. 31 (1): 137-55.

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