Ubc13/UBE2N Antibodies, cDNA Clones Research Reagents

UBE2N (Ubiquitin Conjugating Enzyme E2 N) is a protein coding gene located on human chromosome 12q22. UBE2N is also known as UBC13, UbcH13, HEL-S-71, UbcH-ben, UBCHBEN and UBC13. The human UBE2N gene encodes a 17138 Da protein containing 152 amino acids. The UBE2N protein is ubiquitously expressed in testis, brain and other tissues. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Diseases associated with the TLR signaling cascade. UBE2N is related to ubiquitin-protein transferase activity. UBE2NL is an important paralog of UBE2N gene. UBE2N is associated with some diseases, including Riddle Syndrome and Machado-Joseph Disease.

Ubc13/UBE2N Antibody (2)

    Ubc13/UBE2N cDNA Clone (45)

    NM_003348.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_080560.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_053928.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    Ubc13/UBE2N の背景知識

    Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that promotes the formation of monomeric p53 that results in its cytoplasmic translocation and subsequent loss of function. In detail, increased UBE2N plays a critical role in the synaptosomal accumulation of mutant huntingtin with age. Moreover, Ube2N gene play an essential role for RIG-I-mediated MAVS (mitochondrial antiviral signaling protein) activation in mouse embryonic fibroblast (MEF).

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