TYK2 Antibodies, cDNA Clones Research Reagents

TYK2 (Tyrosine Kinase 2, also known as JTK1; IMD35), located on 19p13.2, is a Protein Coding gene. The gene produces a 133650 Da protein composed of 1187 amino acids. TYK2 contains a C-terminal protein tyrosine kinase catalytic domain with a consensus ATP-binding site. It has no N-terminal signal peptide or transmembrane domain, suggesting that TYK2 is not a receptor-type protein tyrosine kinase. TYK2 functions downstream of multiple cytokine receptors. Diseases such as Immunodeficiency 35 and Lymphomatoid Papulosis are associated with TYK2.

TYK2 Antibody (1)

    TYK2 cDNA Clone (3)

    NM_003331.4

    In expression vector

    XM_006242586.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    TYK2 の背景知識

    Tyrosine kinase 2 (TYK2) is a non-receptor tyrosine-protein kinase, an enzyme that in humans is encoded by the TYK2 gene. TYK2, together with three other family subtypes, namely, Jak1, Jak2, and Jak3, belong to the JAK family of tyrosine kinases that are involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic lymphoma kinase (ALK). TYK2 functions downstream of multiple cytokine receptors. Genome-wide association studies have linked an SNP (rs34536443) within TYK2 encoding a Proline to Alanine substitution at amino acid 1104, to protection from multiple autoimmune diseases including systemic lupus erythematosus (SLE) and multiple sclerosis (MS). TYK2 has been identified as a crucial protein in signal transduction initiated by interferons or interleukins in mammals.

    TYK2 の参考文献

    • Prutsch N, et al. (2020) Correction: Dependency on the tyk2/stat1/mcl1 axis in anaplastic large cell lymphoma. Leukemia 34 (11): 3105.
    • He X, et al. (2019) Selective tyk2 inhibitors as potential therapeutic agents: A patent review (2015-2018). Expert Opin Ther Pat 29 (2): 137-149.
    • Guan A, et al. (2020) Molecular cloning and functional characterization of duck tyk2. Dev Comp Immunol 102 103474.
    • Gorman JA, et al. (2019) The tyk2-p1104a autoimmune protective variant limits coordinate signals required to generate specialized t cell subsets. Front Immunol 10 44.

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