TrkC Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All TrkC reagents are produced in house and quality controlled, including 11 TrkC Antibody, 1 TrkC ELISA, 39 TrkC Gene, 3 TrkC Lysate, 3 TrkC Protein, 2 TrkC qPCR. All TrkC reagents are ready to use.

TrkC Protein (3)

    TrkC Antibody (11)

      TrkC ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      TrkC cDNA Clone (39)

      NM_001007156.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008746.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_005560427.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      TrkC Lysate (3)

        TrkC の背景知識

        NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

        TrkC の参考文献

        • Tessarollo L, et al. (1993) trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development. 118(2): 463-75.
        • Lamballe F, et al. (1994) Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J Neurosci. 14(1): 14-28.
        • Klein R, et al. (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature. 368(6468): 249-51.

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