TrkB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2, also known as OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB), located on 9q21.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 91999 Da protein composed of 822 amino acids. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.

TrkB Protein (8)

    TrkB Antibody (5)

      TrkB ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      TrkB cDNA Clone (53)

      NM_001007097.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001018064.2

      In expression vector

      NM_001025074.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001163168.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_003432718.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      TrkB Lysate (8)

        TrkB の背景知識

        TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

        TrkB の参考文献

        • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
        • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
        • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.