TRIB2 Proteins, cDNA Clones Research Reagents

All TRIB2 reagents are produced in house and quality controlled, including 30 TRIB2 Gene, 2 TRIB2 Lysate, 2 TRIB2 Protein, 2 TRIB2 qPCR. All TRIB2 reagents are ready to use.

TRIB2 Protein (2)

    TRIB2 cDNA Clone (30)

    NM_021643.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_144551.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    TRIB2 Lysate (2)

      TRIB2 の背景知識

      Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).

      TRIB2 の参考文献

      • Seher, TC. et al., 2000, Curr Biol. 10 (11): 623-9.
      • Keeshan, K. et al., 2006, Cancer Cell. 10 (5): 401-11.
      • Hegedus, Z. et al., 2007, Cell Signal. 19 (2):238-50.
      • Keeshan, K. et al., 2008, Blood Cells Mol Dis. 40 (1): 119-21.
      • Cvetkovic, LV. et al., 2010, J Clin Invest. 120 (3): 713-9.

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