TR4/NR2C2 Antibodies, cDNA Clones Research Reagents

NR2C2 (Nuclear Receptor Subfamily 2 Group C Member 2, also known as TR4; TAK1), located on 3p25.1, is a Protein Coding gene. This gene encodes a protein that belongs to the nuclear hormone receptor family. The gene produces a 65414 Da protein composed of 596 amino acids. NR2C2 binds to a direct repeat regulatory element in the promoter of a variety of target genes and plays a key role in tumorigenesis, lipoprotein regulation, and central nervous system development. Diseases such as Premature Aging and Lateral Myocardial Infarction are associated with NR2C2.

TR4/NR2C2 Antibody (1)

    TR4/NR2C2 cDNA Clone (15)

    BC051670

    クローニングベクター cDNA 製品

    In lentiviral vector

    TR4/NR2C2 qPCR Primer (1)

    TR4/NR2C2 の背景知識

    Testicular nuclear receptor 4 (TR4), also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2), is a transcriptional factor and a member of the nuclear receptor family and shares high homology with the testicular nuclear receptor 2. TR4 was initially cloned from human and rat hypothalamus, prostate, and testes libraries. TR4 binds to a direct repeat regulatory element in the promoter of a variety of target genes and plays a key role in tumorigenesis, lipoprotein regulation, and central nervous system development. Testicular nuclear receptor 4 (TR4) could function as a suppressor in the transcriptional regulation of the HBV core gene expression, which might then influence the development of hepatocellular carcinoma (HCC). The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis.

    TR4/NR2C2 の参考文献

    • Zhang D, et al. (2017) False responses of renilla luciferase reporter control to nuclear receptor tr4. Mol Cell Biochem 430 (1-2): 139-147.
    • Lin SJ, et al. (2014) Minireview: Pathophysiological roles of the tr4 nuclear receptor: Lessons learned from mice lacking tr4. Mol Endocrinol 28 (6): 805-821.
    • Ding XF, et al. (2013) Recent advances in the study of testicular nuclear receptor 4. J Zhejiang Univ Sci B 14 (3): 171-177.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.