TIGIT Proteins, Antibodies, cDNA Clones Research Reagents

TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) is a protein coding gene located on human chromosome 3q13.31. TIGIT is also known as VSIG9, VSTM3 and WUCAM. The human TIGIT gene encodes a 26319 Da protein containing 244 amino acids. The TIGIT protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are Hematopoietic Stem Cells and Lineage-specific Markers and Cell adhesion molecules (CAMs). TIGIT is related to signaling receptor binding. CADM2 is an important paralog of TIGIT gene.

TIGIT Protein (10)

    TIGIT Antibody (5)

      TIGIT cDNA Clone (33)

      NM_173799.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001146325.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_008768765.1

      In expression vector

      In lentiviral vector

      XM_005548101.2

      In expression vector

      XM_002716684.3

      In expression vector

      XM_015129816.1

      In expression vector

      XM_005639508.3

      In expression vector

      TIGIT Lysate (7)

        TIGIT の背景知識

        TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

        TIGIT の参考文献

        • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36:40-45.
        • Bechtel S., et al., (2007), The full-ORF clone resource of the German cDNA consortium.BMC Genomics 8:399-399.
        • Yu X., Harden K., et al.,(2009), The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10:48-57.

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