Thioredoxin/TRX Proteins, Antibodies, cDNA Clones Research Reagents

TXN (Thioredoxin) is a protein coding gene located on human chromosome 9q31.3. TXN is also known as TRX, TRDX and TRX1. The human TXN gene encodes a 11737 Da protein containing 105 amino acids. The TXN protein is ubiquitously expressed in esophagus, colon and other tissues. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Folate Metabolism. TXN is related to oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor. TXNDC2 is an important paralog of TXN gene. TXN is associated with some diseases, including Post-Cardiac Arrest Syndrome and Breast Mucinous Carcinoma.

Thioredoxin/TRX Protein (2)

    Thioredoxin/TRX Antibody (9)

      Thioredoxin/TRX cDNA Clone (15)

      NM_003329.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Thioredoxin/TRX の背景知識

      Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

      Thioredoxin/TRX の参考文献

      • Holmgren A , et al.,1989, J Biol Chem 264 (24): 13963-6.
      • Nordberg J, et al., 2001, Free Radic Biol Med31 (11): 1287-312.
      • Mustacich D, et al., 2000, Biochem J 346 (Pt 1): 1-8. 
      • Mitchell D.A., et al., 2005, Nat. Chem. Biol. 1:154-158.

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