ST6GAL1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) is a protein coding gene located on human chromosome 3q27.3. ST6GAL1 is also known as ST6N, SIAT1 and ST6GalI. The human ST6GAL1 gene encodes a 46605 Da protein containing 406 amino acids. The ST6GAL1 protein is broadly expressed in liver, lymph node and other tissues. Among its related pathways are Transport to the Golgi and subsequent modification and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). ST6GAL1 is related to sialyltransferase activity and beta-galactoside alpha-2,6-sialyltransferase activity. ST6GAL2 is an important paralog of ST6GAL1 gene. ST6GAL1 is associated with some diseases, including Colon Adenocarcinoma and Puerperal Pulmonary Embolism.

ST6GAL1 Protein (3)

    ST6GAL1 Antibody (5)

      ST6GAL1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      ST6GAL1 cDNA Clone (52)

      NM_003032.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_145933.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001113344.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_005639812.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ST6GAL1 Lysate (3)

        ST6GAL1 の背景知識

        Beta-galactoside alpha-2,6-sialyltransferase 1, also known as B-cell antigen CD75, Sialyltransferase 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6GAL1 and SIAT1, is a single-pass type II membrane protein that belongs to the glycosyltransferase 29 family. Sialyltransferases are key enzymes in the biosynthesis of sialoglycoconjugates that catalyze the transfer of sialic residue from its activated form to an oligosaccharidic acceptor. ST6GAL1 / SIAT1 is normally found in the Golgi but can be proteolytically processed to a soluble form. It is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. β-Galactoside α2,6-sialyltransferases ST6GAL1 and ST6GAL2 are the two unique members of the ST6GAL family described in higher vertebrates. ST6GAL1 / SIAT1 transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.

        ST6GAL1 の参考文献

        • Collins,B.E. et al., 2006, Nat Immunol. 7(2):199-206.
        • Videira,P.A. et al., 2008, Glycoconj J. 25(3): 259-68.
        • Petit,D. et al., 2010, J Biol Chem. 285(49): 38399-414.
        • Kroes,R.A. et al., 2010, Proc Natl Acad Sci USA.107(28):12646-51.

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