ST2/IL-1 RL1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL1RL1 (Interleukin 1 Receptor-Like 1, also known as T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R), located on 2q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 63358 Da protein composed of 556 amino acids. The protein encoded by this gene is a member of the interleukin 1 receptor family. Diseases such as Allergic Conjunctivitis and Loeffler Syndrome are associated with IL1RL1. The related pathways of IL1RL1 include PEDF Induced Signaling and the Innate Immune System.

ST2/IL-1 RL1 Protein (7)

    ST2/IL-1 RL1 Antibody (11)

      ST2/IL-1 RL1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      ST2/IL-1 RL1 cDNA Clone (28)


      クローニングベクター cDNA 製品

      In lentiviral vector


      In expression vector


      クローニングベクター cDNA 製品

      In lentiviral vector


      In expression vector

      ST2/IL-1 RL1 qPCR Primer (1)

      ST2/IL-1 RL1 Lysate (7)

        ST2/IL-1 RL1 の背景知識

        IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.

        ST2/IL-1 RL1 の参考文献

        • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
        • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.

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