SPARCL1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SPARCL1 (SPARC Like 1) is a protein coding gene located on human chromosome 4q22.1. SPARCL1 is also known as SC1, MAST9, PIG33 and MAST 9. The human SPARCL1 gene encodes a 75208 Da protein containing 664 amino acids. The SPARCL1 protein is broadly expressed in brain, endometrium and other tissues. SPARCL1 is related to calcium ion binding. SPARC is an important paralog of SPARCL1 gene. SPARCL1 is associated with some diseases, such as Entropion.

SPARCL1 Protein (2)

    SPARCL1 Antibody (14)

      SPARCL1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      SPARCL1 cDNA Clone (42)

      NM_004684.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010097.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      BC061755.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      In expression vector

      XM_005639162.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      SPARCL1 Lysate (2)

        SPARCL1 の背景知識

        SPARC-like protein 1 (SPARCL1; also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. Besides, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).

        SPARCL1 の参考文献

        • Sullivan MM, et al. (2004) Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family. Int J Biochem Cell Biol. 36(6): 991-6.
        • Esposito I, et al. (2007) Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. Neoplasia. 9(1): 8-17.
        • Weimer JM, et al. (2008) A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system. Glia. 56(9): 935-41.

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