Sonic Hedgehog Proteins, Antibodies, cDNA Clones Research Reagents

All Sonic Hedgehog reagents are produced in house and quality controlled, including 2 Sonic Hedgehog Antibody, 26 Sonic Hedgehog Gene, 4 Sonic Hedgehog Lysate, 4 Sonic Hedgehog Protein, 2 Sonic Hedgehog qPCR. All Sonic Hedgehog reagents are ready to use.

Sonic Hedgehog Protein (4)

    Sonic Hedgehog Antibody (2)

      Sonic Hedgehog cDNA Clone (26)

      NM_000193.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_009170.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      Sonic Hedgehog Lysate (4)

        Sonic Hedgehog の背景知識

        Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog binds to the patched receptor, which functions in association with smoothened, to activate the transcription of target genes. In the absence of sonic HedgeHog, patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor, the gli oncogene. Defects in sonic hedgehog can cause microphthalmia isolated with coloboma type 5, triphalangeal thumb-polysyndactyly syndrome and holoprosencephaly type 3.

        Sonic Hedgehog の参考文献

        • Ericson J, et al. (1997) Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harb Symp Quant Biol. 62:451-66.
        • Marigo V, et al. (1996) Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci. 93(18):9346-51.
        • Stone DM, et al. (1996) he tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 384:129-34.

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