SMAC Proteins, Antibodies, cDNA Clones Research Reagents

All SMAC reagents are produced in house and quality controlled, including 8 SMAC Antibody, 45 SMAC Gene, 2 SMAC IP Kit, 1 SMAC Protein, 1 SMAC qPCR. All SMAC reagents are ready to use.

SMAC Protein (1)

    SMAC Antibody (8)

      SMAC cDNA Clone (45)

      NM_019887.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_023232.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_005572484.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      SMAC qPCR Primer (1)

      SMAC の背景知識

      Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring downstream of cytochrome c release in response to apoptotic stimuli such as irradiation, DNA damage or cytotoxic drugs. In the cytosol, Smac/Diablo interacts and antagonizes inhibitors of apoptosis proteins (IAPs), thus allowing the activation of caspases and apoptosis. This activity has prompted the synthesis of peptidomimetics that could potentially be used in cancer therapy. The role of Smac/DIABLO in colorectal carcinogenesis is ill defined. Data continues to accumulate to suggest that decreased levels of Smac/DIABLO may be important in chemoradiation-resistance to apoptosis in advanced colon cancer.

      SMAC の参考文献

      • Korga A, et al. (2006) Role of mitochondrial protein Smac/Diablo in regulation of apoptotic pathways Pol Merkur Lekarski. 20(119): 573-6.
      • Anguiano-Hernandez YM, et al. (2007) Smac/DIABLO and colon cancer. Anticancer Agents Med Chem. 7(4): 467-73.
      • Martinez-Ruiz G, et al. (2008) Role of Smac/DIABLO in cancer progression. J Exp Clin Cancer Res. 27: 48.

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