SLAMF6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SLAMF6 (SLAM Family Member 6) is a protein coding gene located on human chromosome 1q23.2-q23.3. SLAMF6 is also known as KALI, NTBA, CD352, KALIb, Ly108, NTB-A and SF2000. The human SLAMF6 gene encodes a 37345 Da protein containing 332 amino acids. The SLAMF6 protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. SLAMF7 is an important paralog of SLAMF6 gene. SLAMF6 is associated with some diseases, including Lymphoproliferative Syndrome and Bare Lymphocyte Syndrome, Type I.

SLAMF6 Protein (4)

    SLAMF6 Antibody (19)

      SLAMF6 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      SLAMF6 cDNA Clone (15)

      BC114495

      In expression vector

      In lentiviral vector

      NM_030710.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      SLAMF6 Lysate (4)

        SLAMF6 の背景知識

        SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

        SLAMF6 の参考文献

        • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
        • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
        • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
        • Claus M. et al., 2007, Front Biosci. 13: 956-65.

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