SLAMF6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All SLAMF6 reagents are produced in house and quality controlled, including 19 SLAMF6 Antibody, 2 SLAMF6 ELISA, 15 SLAMF6 Gene, 1 SLAMF6 IP Kit, 4 SLAMF6 Lysate, 4 SLAMF6 Protein, 2 SLAMF6 qPCR. All SLAMF6 reagents are ready to use.

SLAMF6 Protein (4)

    SLAMF6 Antibody (19)

      SLAMF6 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      SLAMF6 cDNA Clone (15)

      BC114495

      In expression vector

      In lentiviral vector

      NM_030710.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      SLAMF6 Lysate (4)

        SLAMF6 の背景知識

        SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

        SLAMF6 の参考文献

        • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
        • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
        • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
        • Claus M. et al., 2007, Front Biosci. 13: 956-65.

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