SIGLEC5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All SIGLEC5 reagents are produced in house and quality controlled, including 11 SIGLEC5 Antibody, 1 SIGLEC5 ELISA, 14 SIGLEC5 Gene, 2 SIGLEC5 Lysate, 2 SIGLEC5 Protein, 1 SIGLEC5 qPCR. All SIGLEC5 reagents are ready to use.

SIGLEC5 Protein (2)

    SIGLEC5 Antibody (11)

      SIGLEC5 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      SIGLEC5 cDNA Clone (14)

      NM_003830.3

      クローニングベクター cDNA 製品

      NM_145581.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      SIGLEC5 qPCR Primer (1)

      SIGLEC5 Lysate (2)

        SIGLEC5 の背景知識

        SIGLEC5 contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. It belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 is expressed by monocytic/myeloid lineage cells. It is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is also expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

        SIGLEC5 の参考文献

        • Angata T, et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20(12):1964-73.
        • Avril T, et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem. 280(20):19843-51.
        • Erickson-Miller CL, et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp Hematol. 31(5):382-8.

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