SerpinA10 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All SerpinA10 reagents are produced in house and quality controlled, including 3 SerpinA10 Antibody, 26 SerpinA10 Gene, 1 SerpinA10 Lysate, 1 SerpinA10 Protein, 2 SerpinA10 qPCR. All SerpinA10 reagents are ready to use.

SerpinA10 Protein (1)

    SerpinA10 Antibody (3)

      SerpinA10 cDNA Clone (26)

      NM_001100607.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_144834.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      SerpinA10 Lysate (1)

        SerpinA10 の背景知識

        Protein Z-dependent protease inhibitor, also known as PZ-dependent protease inhibitor, SERPINA1 and ZPI, is a secreted protein which belongs to theserpin family. It is expressed by the liver and secreted in plasma. SERPINA1 / Serpin-A1 inhibits factor Xa activity in the presence of protein Z, calcium and phospholipid. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors).Over 1 serpins have now been identified, these include 36 human proteins, as well as molecules in plants, fungi, bacteria, archaea and certain viruses. Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site.

        SerpinA10 の参考文献

        • Han X, et al., 1998, Proc Natl Acad Sci. USA  95: 9250-5.
        • Han X, et al., 2000, Blood 96: 3049-55.
        • Irving JA, et al.,2000, Genome Res. 10 (12): 1845-64.
        • Irving J, et al.,2002, Mol Biol Evol. 19 (11): 1881-90.
        • Rawlings ND, et al.,2004, Biochem J. 378 (Pt 3): 705-16.
        • Water N, et al., 2004, Br J Haematol. 127:190-4.
        • Wei Z, et al., 2009, Blood 114 (17): 3662-7.
        • Whisstock JC, et al.,2010, J Biol Chem. 285 (32): 24307-12.

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