Serglycin Proteins, Antibodies, cDNA Clones Research Reagents

SRGN (Serglycin) is a protein coding gene located on human chromosome 10q22.1. SRGN is also known as PPG, PRG and PRG1. The human SRGN gene encodes a 17652 Da protein containing 158 amino acids. The SRGN protein is biasedly expressed in bone marrow, appendix and other tissues. Among its related pathways are Response to elevated platelet cytosolic Ca2+. SRGN is related to collagen binding. SRGN is associated with some diseases, including Mucinoses and Glossopharyngeal Neuralgia.

Serglycin Protein (2)

    Serglycin Antibody (1)

      Serglycin cDNA Clone (26)

      BC015516

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011157.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Serglycin qPCR Primer (1)

      Serglycin Lysate (2)

        Serglycin の背景知識

        SRGN is known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of various hematopoietic cells has a protease-resistant peptide core, and is vital for neutralizing hydrolytic enzymes. SRGN is associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. It is required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. SRGN also plays a role in localizing neutrophil elastase in azurophil granules of neutrophils.

        Serglycin の参考文献

        • Hatton MN. et al., 1985, Biochem J. 230 (3): 817-20.
        • Schick BP. et al., 1995, J Cell Physiol. 165 (1): 96-106.
        • Kato S. et al., 1995, Gene. 150 (2): 243-50.

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