SEMA4A Proteins, Antibodies, cDNA Clones Research Reagents

SEMA4A (Semaphorin 4A) is a protein coding gene located on human chromosome 1q22. SEMA4A is also known as RP35, SEMB, SEMAB and CORD10. The human SEMA4A gene encodes an 83574 Da protein containing 761 amino acids. The SEMA4A protein is broadly expressed in skin, lymph node and other tissues. Among its related pathways are Axon guidance and Developmental Biology. SEMA4B is an important paralog of SEMA4A gene. SEMA4A is associated with some diseases, including Retinitis Pigmentosa 35 and Cone-Rod Dystrophy 10.

SEMA4A Protein (2)

    SEMA4A Antibody (2)

      SEMA4A cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      SEMA4A qPCR Primer (1)

      SEMA4A Lysate (2)

        SEMA4A の背景知識

        Semaphorin-4A, also known as Semaphorin-B, SEMA4A, Sema B and SEMAB, is a single-pass type I membrane protein that belongs to the semaphorin family. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Semaphorin-4A / SEMA4A contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Defects in SEMA4A are the cause of retinitis pigmentosa type 35 (RP35) which leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of mid-peripheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in SEMA4A are also the cause of cone-rod dystrophy type 1 (CORD1) which are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 2 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration.

        SEMA4A の参考文献

        • Clark H.F., et al., 2003, Genome Res. 13: 2265-2270.
        • Ota T., et al., 2004,Nat. Genet. 36: 40-45.
        • Neufeld, G. et al., 2005, Front Biosci. 10 : 751-60.
        • Fiore,R. et al., 2005, Mol Cell Biol. 25 (6):2310-9.
        • Abid A., et al., 2006, J. Med. Genet. 43:378-381.

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