S100A9 Proteins, Antibodies, cDNA Clones Research Reagents

S100A9 (S100 Calcium Binding Protein A9) is a protein coding gene located on human chromosome 1q21.3. S100A9 is also known as MIF, NIF, P14, CAGB, CFAG, CGLB, L1AG, LIAG, MRP14, 60B8AG and MAC387. The human S100A9 gene encodes a 13242 Da protein containing 114 amino acids. The S100A9 protein is biasedly expressed in bone marrow, esophagus and other tissue. Among its related pathways are Activated TLR4 signalling and IL1 and megakaryocytes in obesity. S100A9 is related to calcium ion binding and microtubule binding. S100A12 is an important paralog of S100A9 gene. S100A9 is associated with some diseases, including Cystic Fibrosis and Juvenile Rheumatoid Arthritis.

S100A9 Protein (3)

    S100A9 Antibody (8)

      S100A9 cDNA Clone (27)

      NM_002965.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_009114.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      S100A9 Lysate (1)

        S100A9 の背景知識

        S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A9, also known as S100 calciumbinding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a calcium-binding protein. It has anti-microbial activity towards bacteria and fungi. The anti-microbial and proapoptotic activity of S100A9 is inhibited by zinc ions. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. S100A9 plays a role as a proinflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.

        S100A9 の参考文献

        • Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23.
        • Fanò G. et al., 1995, Prog Neurobiol. 46 (1): 71-82.
        • Vogl T. et al., 2004, Blood. 104: 4260-8.
        • Viemann D. et al., 2005, Blood. 105: 2955-62.
        • Nakatani Y. et al., 2005, Mediators Inflamm. 2005: 280-92.
        • Bjoerk P. et al., 2009, PLoS Biol. 7: E97-E97.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.