RSPO2 Proteins, cDNA Clones Research Reagents

RSPO2 (R-Spondin 2) is a protein coding gene located on human chromosome 8q23.1. RSPO2 is also known as HHRRD, TETAMS2 and CRISTIN2. The human RSPO2 gene encodes a 28315 Da protein containing 243 amino acids. The RSPO2 protein is biasedly expressed in brain, placenta and other tissues. Among its related pathways are Signaling by GPCR and Signaling by Wnt. RSPO2 is related to signaling receptor binding and G protein-coupled receptor binding. RSPO3 is an important paralog of RSPO2 gene. RSPO2 is associated with some diseases, including Humerofemoral Hypoplasia With Radiotibial Ray Deficiency and Tetraamelia Syndrome 2.

RSPO2 Protein (2)

    RSPO2 cDNA Clone (26)


    クローニングベクター cDNA 製品

    In lentiviral vector


    クローニングベクター cDNA 製品

    In lentiviral vector

    RSPO2 Lysate (2)

      RSPO2 の背景知識

      R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.

      RSPO2 の参考文献

      • Cadieu E, et al. (2009) Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science. 326: 150-153.
      • Kazanskaya O, et al. (2004) R-Spondin2 is a secreted activator of Wnt / beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell. 7(4): 525-34.
      • Parker HG, et al. (2010) An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered. 101(5):612-7.

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