RSK4 Proteins, cDNA Clones Research Reagents

RPS6KA6 (Ribosomal Protein S6 Kinase A6) is a protein coding gene located on human chromosome Xq21.1. RPS6KA6 is also known as RSK4, RSK-4, p90RSK6, PP90RSK4, and S6K-alpha-6. The human RPS6KA6 gene encodes an 83872 Da protein containing 745 amino acids. The RPS6KA6 protein is broadly expressed in thyroid, kidney and other tissues. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins, and Transmission across Chemical Synapses. RPS6KA6 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. RPS6KA3 is an important paralog of RPS6KA6 gene. RPS6KA6 is associated with some diseases, including Coffin-Lowry Syndrome and Adrenal Cortical Adenocarcinoma.

RSK4 Protein (1)

    RSK4 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    RSK4 qPCR Primer (1)

    RSK4 Lysate (1)

      RSK4 の背景知識

      Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RPS6KA6 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RPS6KA6 plays a role in normal neuronal development. Further mutation analyses in males with X-linked mental retardation must prove that the gene of RPS6KA6 is indeed a novel MRX gene. RPS6KA6 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA6 is activated by multiple phosphorylations on threonine and serine residues.

      RSK4 の参考文献

      • Yntema H.G., et al.,(1999), A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. Genomics 62:332-343.
      • Ross M.T., et al., (2005), The DNA sequence of the human X chromosome.Nature 434:325-337.
      • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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