RSK3 Proteins, Antibodies, cDNA Clones Research Reagents

RPS6KA2 (Ribosomal Protein S6 Kinase A2) is a protein coding gene located on human chromosome 6q27. RPS6KA2 is also known as RSK, HU-2, RSK3, p90RSK2, p90-RSK3, pp90RSK3, MAPKAPK1C, S6K-alpha and S6K-alpha2. The human RPS6KA2 gene encodes an 83239 Da protein containing 733 amino acids. The RPS6KA2 protein is ubiquitously expressed in thyroid, lung and other tissues. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Nuclear Events (kinase and transcription factor activation). RPS6KA2 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. RPS6KA3 is an important paralog of RPS6KA2 gene. RPS6KA2 is associated with some diseases, including Coffin-Lowry Syndrome and Dyskeratosis Congenita, Autosomal Dominant 3.

RSK3 Protein (1)

    RSK3 Antibody (1)

      RSK3 cDNA Clone (29)

      NM_021135.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_002803991.1

      クローニングベクター cDNA 製品

      RSK3 qPCR Primer (1)

      RSK3 Lysate (1)

        RSK3 の背景知識

        Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest, increased apoptosis, reduced levels of phosphorylated extracellular signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 / RSK-3 contains one AGC-kinase C-terminal domain and two protein kinase domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It transiently dissociates following mitogenic stimulation. RPS6KA2 / RSK-3 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation.

        RSK3 の参考文献

        • Zhao Y., et al.,(1995), RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol. Cell. Biol. 15:4353-4363.
        • Mungall A.J., et al., (2003), The DNA sequence and analysis of human chromosome 6.Nature 425:805-811.
        • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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