ROBO4 Proteins, Antibodies, cDNA Clones Research Reagents

ROBO4 (Roundabout Guidance Receptor 4) is a protein coding gene located on human chromosome 11q24.2. ROBO4 is also known as MRB, AOVD3 and ECSM4. The human ROBO4 gene encodes a 107457 Da protein containing 1007 amino acids. The ROBO4 protein is broadly expressed in fat, spleen and other tissues. Among its related pathways is Development Slit-Robo signaling. SDK1 is an important paralog of ROBO4 gene. ROBO4 is associated with some diseases, including Aortic Valve Disease 3 and Diaphragmatic Hernia, Congenital.

ROBO4 Protein (2)

    ROBO4 Antibody (7)

      ROBO4 cDNA Clone (16)


      In expression vector

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      ROBO4 Lysate (2)

        ROBO4 の背景知識

        Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.

        ROBO4 の参考文献

        • Huminiecki L., et al., 2002, Genomics 79:547-552.
        • Park,K.W. et al., 2003,Dev Biol. 261 (1):251-67.
        • Yoshikawa,M. et al., 2008, Protein Expr Purif. 61 (1):78-82.
        • Jones,C.A. et al., 2008, Nat Med. 14 (4):448-53.
        • Koch,A.W. et al., 2011, Dev Cell. 20 (1):33-46.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.