Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and consequently cell survival. PHB2 is a member of the SFPH trans-membrane family proteins and is present in various cellular compartments including the nucleus and mitochondria. Recent studies have identified PHB2 as a multifunctional protein that controls cell proliferation, apoptosis, cristae morphogenesis, and the functional integrity of mitochondria. PHB2 is an inner mitochondrial membrane protein that participates in parkin-induced mitophagy. PHB2 has multiple functions, such as transcriptional regulation and cell viability and development.