REA/PHB2 Antibodies, cDNA Clones Research Reagents

PHB2 (Prohibitin 2, also known as BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141), located on 12p13.31, is a Protein Coding gene. The gene produces a 33296 Da protein composed of 299 amino acids. PHB2 is a member of the SFPH trans-membrane family proteins and is present in various cellular compartments including the nucleus and mitochondria. PHB2 has multiple functions, such as transcriptional regulation and cell viability and development. Diseases such as Breast Medullary Carcinoma and 3-Methylglutaconic Aciduria, Type V are associated with PHB2.

REA/PHB2 Antibody (1)

    REA/PHB2 cDNA Clone (62)

    NM_001144831.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_007531.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001013035.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_004766629.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001266316.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    REA/PHB2 の背景知識

    Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and consequently cell survival. PHB2 is a member of the SFPH trans-membrane family proteins and is present in various cellular compartments including the nucleus and mitochondria. Recent studies have identified PHB2 as a multifunctional protein that controls cell proliferation, apoptosis, cristae morphogenesis, and the functional integrity of mitochondria. PHB2 is an inner mitochondrial membrane protein that participates in parkin-induced mitophagy. PHB2 has multiple functions, such as transcriptional regulation and cell viability and development.

    REA/PHB2 の参考文献

    • Zhang H, et al. (2020) Prohibitin 2/phb2 in parkin-mediated mitophagy: A potential therapeutic target for non-small cell lung carcinoma. Med Sci Monit 26 e923227.
    • Yan C, et al. (2020) Phb2 (prohibitin 2) promotes pink1-prkn/parkin-dependent mitophagy by the parl-pgam5-pink1 axis. Autophagy 16 (3): 419-434.
    • Xu T, et al. (2014) Expression of phb2 in rat brain cortex following traumatic brain injury. Int J Mol Sci 15 (2): 3299-3318.
    • Takata H, et al. (2007) Phb2 protects sister-chromatid cohesion in mitosis. Curr Biol 17 (15): 1356-1361.

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