PYCARD Antibodies, cDNA Clones Research Reagents

PYCARD (PYD And CARD Domain Containing, also known as ASC; TMS; TMS1; CARD5; TMS-1), located on 16p11.2, is a Protein Coding gene. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: an N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The gene produces a 21627 Da protein composed of 195 amino acids. The protein contains an N-terminal pyrin-like domain (PYD) and an 87-residue C-terminal CARD. Diseases such as Chronic Recurrent Multifocal Osteomyelitis and Muckle-Wells Syndrome are associated with PYCARD.

PYCARD Antibody (1)

    PYCARD cDNA Clone (16)

    NM_013258.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_023258.4

    In expression vector

    PYCARD qPCR Primer (1)

    PYCARD の背景知識

    PYCARD (PYD And CARD Domain Containing) is a Protein Coding gene. The PYCARD gene, located on 16p11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog. ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence indicates that ASC and these NLRs also elicit non-overlapping functions. During inflammasome assembly, the apoptosis-associated speck-like protein containing a CARD (PYCARD, commonly known as ASC) adaptor protein polymerizes into large, filamentous clusters termed ASC specks that are released upon cytolysis. Specks are resistant to proteolytic degradation because of their prion-like structure and therefore might serve as a biomarker for pyroptotic cell death in myelodysplastic syndromes.

    PYCARD の参考文献

    • Taxman DJ, et al. (2011) The nlr adaptor asc/pycard regulates dusp10, mitogen-activated protein kinase (mapk), and chemokine induction independent of the inflammasome. J Biol Chem 286 (22): 19605-19616.
    • Basiorka AA, et al. (2018) Assessment of asc specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: An observational cohort study. Lancet Haematol 5 (9): e393-e402.

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