PYCARD (PYD And CARD Domain Containing) is a Protein Coding gene. The PYCARD gene, located on 16p11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog. ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence indicates that ASC and these NLRs also elicit non-overlapping functions. During inflammasome assembly, the apoptosis-associated speck-like protein containing a CARD (PYCARD, commonly known as ASC) adaptor protein polymerizes into large, filamentous clusters termed ASC specks that are released upon cytolysis. Specks are resistant to proteolytic degradation because of their prion-like structure and therefore might serve as a biomarker for pyroptotic cell death in myelodysplastic syndromes.