PSME3 Proteins, Antibodies, cDNA Clones Research Reagents

PSME3 (Proteasome Activator Subunit 3) is a protein coding gene located on human chromosome 17q21.31. PSME3 is also known as Ki, PA28G, HEL-S-283, PA28gamma, REG-GAMMA and PA28-gamma. The human PSME3 gene encodes a 29506 Da protein containing 254 amino acids. The PSME3 protein is ubiquitously expressed in esophagus, urinary bladder and other tissues. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Antigen processing-Cross presentation. PSME3 is related to identical protein binding and MDM2/MDM4 family protein binding. PSME1 is an important paralog of PSME3 gene.

PSME3 Protein (1)

    PSME3 Antibody (2)

      PSME3 cDNA Clone (15)

      BC001423

      クローニングベクター cDNA 製品

      In lentiviral vector

      PSME3 qPCR Primer (1)

      PSME3 の背景知識

      PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME3 gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring.

      PSME3 の参考文献

      • Albertsen HM. et al., 1994, Nat Genet. 7 (4): 472-9.
      • Zhang Zhuo. et al., 2008, EMBO J. 27 (6): 852-64.
      • Coux O. et al., 1996, Annu Rev Biochem. 65: 801-47.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.