PSMA Proteins, Antibodies, cDNA Clones Research Reagents

All PSMA reagents are produced in house and quality controlled, including 2 PSMA Antibody, 39 PSMA Gene, 1 PSMA IP Kit, 3 PSMA Lysate, 4 PSMA Protein, 2 PSMA qPCR. All PSMA reagents are ready to use.

PSMA Protein (4)

    PSMA Antibody (2)

      PSMA cDNA Clone (39)

      NM_004476.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001014986.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_016770.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      PSMA Lysate (3)

        PSMA の背景知識

        Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.

        PSMA の参考文献

        • Israeli R.S., et al.,(1993), Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53:227-230.
        • Su S.L., et al., (1995), Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.Cancer Res. 55:1441-1443.
        • O'Keefe D.S., et al.,(1998), Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.Biochim. Biophys. Acta 1443:113-127.

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