Protein Kinase D2/PRKD2 Proteins, Antibodies, cDNA Clones Research Reagents

PRKD2 (Protein Kinase D2) is a protein coding gene located on human chromosome 19q13.32. PRKD2 is also known as PKD2, HSPC187 and nPKC-D2. The human PRKD2 gene encodes a 96722 Da protein containing 878 amino acids. The PRKD2 protein is ubiquitously expressed in spleen, lymph node and other tissues. Among its related pathways are Ras signaling pathway and Development Slit-Robo signaling. PRKD2 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PRKD1 is an important paralog of PRKD2 gene. PRKD2 is associated with some diseases, including Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease and Angiolipoma.

Protein Kinase D2/PRKD2 Protein (1)

    Protein Kinase D2/PRKD2 Antibody (1)

      Protein Kinase D2/PRKD2 cDNA Clone (14)

      NM_016457.4
      NM_001013895.1

      クローニングベクター cDNA 製品

      Protein Kinase D2/PRKD2 qPCR Primer (1)

      Protein Kinase D2/PRKD2 Lysate (1)

        Protein Kinase D2/PRKD2 の背景知識

        Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 and phosphorylation of Ser-76 by PKC relieves auto-inhibition by the PH domain. PRKD2 / PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.

        Protein Kinase D2/PRKD2 の参考文献

        • Zhang QH, et al., 2000, Genome Res 10 (10): 1546-60.
        • Di Bernardo MC, et al.,2008, Nature genetics. 40 (10) :1204-10.
        • Zhang L, et al., 2009, American journal of nephrology. 30 (6) :505-13.

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