Prolactin Receptor Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PRLR (Prolactin Receptor) is a protein coding gene located on human chromosome 5p13.2. PRLR is also known as HPRL, MFAB, hPRLrI and RI-PRLR. The human PRLR gene encodes a 69506 Da protein containing 622 amino acids. The PRLR protein is biasedly expressed in placenta, endometrium and other tissues. Among its related pathways are Prolactin Signaling Pathway and PEDF Induced Signaling. PRLR is related to protein homodimerization activity and peptide hormone binding. GHR is an important paralog of PRLR gene. PRLR is associated with some diseases, including Hyperprolactinemia and Multiple Fibroadenomas Of The Breast.

Prolactin Receptor Protein (4)

    Prolactin Receptor Antibody (15)

      Prolactin Receptor ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      Prolactin Receptor cDNA Clone (39)

      NM_000949.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011169.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001034111.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Prolactin Receptor Lysate (4)

        Prolactin Receptor の背景知識

        Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type â… cytokine receptor superfamily, and contains two fibronectin type-â…¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.

        Prolactin Receptor の参考文献

        • Bole-Feysot C, et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-68.
        • Goffin V, et al. (1999) From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 15(3-5): 189-201.
        • Li Y, et al. (2006) Stabilization of prolactin receptor in breast cancer cells. Oncogene. 25(13): 1896-902.
        • Shao R, et al. (2008) Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice. Biol Reprod. 79(4): 748-57.

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