pro renin receptor/ATP6AP2 Antibodies, cDNA Clones Research Reagents

All pro renin receptor/ATP6AP2 reagents are produced in house and quality controlled, including 1 pro renin receptor/ATP6AP2 Antibody, 28 pro renin receptor/ATP6AP2 Gene, 2 pro renin receptor/ATP6AP2 qPCR. All pro renin receptor/ATP6AP2 reagents are ready to use.

pro renin receptor/ATP6AP2 Antibody (1)

    pro renin receptor/ATP6AP2 cDNA Clone (28)

    NM_005765.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_027439.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001007091.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    pro renin receptor/ATP6AP2 の背景知識

    ATP6AP2 (also known as the (pro)renin receptor) is a type I transmembrane protein that can be cleaved into two fragments in the Golgi apparatus. While in Drosophila ATP6AP2 functions in the planar cell polarity (PCP) pathway, recent human genetic studies have suggested that ATP6AP2 could participate in the assembly of the V-ATPase in the endoplasmic reticulum (ER). The (pro)renin receptor [(P)RR], also known as ATP6AP2 [ATPase 6 accessory protein 2], is highly expressed in the brain. ATP6AP2 plays a role in early brain development, adult hippocampal neurogenesis and in cognitive functions. Lack of ATP6AP2 has deleterious effects, and mutations of ATP6AP2 in humans are associated with, e.g. X-linked intellectual disability. The (pro)renin receptor [(P)RR, ATP6AP2] is a multifunctional transmembrane protein that activates local renin-angiotensin systems, but also interacts with Wnt pathways and vacuolar H(+) -ATPase (V-ATPase) during organogenesis. ATP6AP2 mutations in humans. Our results identify ATP6AP2 as an essential gene for the nervous system.

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