PRMT5 Proteins, Antibodies, cDNA Clones Research Reagents

PRMT5 (Protein Arginine Methyltransferase 5) is a protein coding gene located on human chromosome 14q11.2. PRMT5 is also known as HSL7, JBP1, SKB1, IBP72, SKB1Hs and HRMT1L5. The human PRMT5 gene encodes a 72684 Da protein containing 637 amino acids. The PRMT5 protein is ubiquitously expressed in thyroid, ovary and other tissues. Among its related pathways are Transport of the SLBP independent Mature mRNA and E2F transcription factor network. PRMT5 is related to protein heterodimerization activity and transcription corepressor activity. PRMT5 is associated with some diseases, such as Mantle Cell Lymphoma.

PRMT5 Protein (1)

    PRMT5 Antibody (2)

      PRMT5 cDNA Clone (45)

      NM_006109.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013768.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001108867.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      PRMT5 Lysate (1)

        PRMT5 の背景知識

        Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. Protein arginine methyltransferase 5 (PRMT5) is a member of the protein arginine N-methyltransferases (PRMT)family, and exists as at least homodimers and homotetramers, or homooligomers mediated by disulfide bonds and non-covalent association ubiquitously. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), and thus plays a role in the assembly and biogenesis of snRNP core particles. PRMT5 methylates histone H2A and H4 'Arg-3' during germ cell development, as well as histone H3 'Arg-8', which may repress transcription. PRMT5 also methylates SUPT5H and regulates its transcriptional elongation properties. Additionally, it is also suggested that PRMT5 negatively regulates cyclin E1 promoter activity and cellular proliferation.

        PRMT5 の参考文献

        • Rho. J. et al., 2001, J.Biol. Chem. 276: 11393-11401.
        • Fabbrizio, E.et al., 2002, EMBO.Rep. 3: 641-645.
        • Azzouz, T.N. et al., 2005, J.Biol. Chem. 280: 34435-34440.
        • Pal, S., et al., 2004, Mol. Cell. Biol. 24:9630-9645.
        • Herrmann, FJ. et al., 2009, Cell Sci. 122 (Pt 5): 667-77.

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