PRMT5 Proteins, Antibodies, cDNA Clones Research Reagents

All PRMT5 reagents are produced in house and quality controlled, including 2 PRMT5 Antibody, 45 PRMT5 Gene, 1 PRMT5 Lysate, 1 PRMT5 Protein, 3 PRMT5 qPCR. All PRMT5 reagents are ready to use.

PRMT5 Protein (1)

    PRMT5 Antibody (2)

      PRMT5 cDNA Clone (45)

      NM_006109.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013768.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001108867.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      PRMT5 Lysate (1)

        PRMT5 の背景知識

        Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. Protein arginine methyltransferase 5 (PRMT5) is a member of the protein arginine N-methyltransferases (PRMT)family, and exists as at least homodimers and homotetramers, or homooligomers mediated by disulfide bonds and non-covalent association ubiquitously. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), and thus plays a role in the assembly and biogenesis of snRNP core particles. PRMT5 methylates histone H2A and H4 'Arg-3' during germ cell development, as well as histone H3 'Arg-8', which may repress transcription. PRMT5 also methylates SUPT5H and regulates its transcriptional elongation properties. Additionally, it is also suggested that PRMT5 negatively regulates cyclin E1 promoter activity and cellular proliferation.

        PRMT5 の参考文献

        • Rho. J. et al., 2001, J.Biol. Chem. 276: 11393-11401.
        • Fabbrizio, E.et al., 2002, EMBO.Rep. 3: 641-645.
        • Azzouz, T.N. et al., 2005, J.Biol. Chem. 280: 34435-34440.
        • Pal, S., et al., 2004, Mol. Cell. Biol. 24:9630-9645.
        • Herrmann, FJ. et al., 2009, Cell Sci. 122 (Pt 5): 667-77.

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