Podoplanin Proteins, Antibodies, cDNA Clones Research Reagents

PDPN (Podoplanin) is a protein coding gene located on human chromosome 1p36.21. PDPN is also known as T1A, GP36, GP40, Gp38, OTS8, T1A2, TI1A, T1A-2, AGGRUS, HT1A-1 and PA2.26. The human PDPN gene encodes a 16698 Da protein containing 162 amino acids. The PDPN protein is biasedly expressed in placenta, urinary bladder and other tissues. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Angiogenesis (CST). PDPN is related to amino acid transmembrane transporter activity and folic acid transmembrane transporter activity. PDPN is associated with some diseases, including Lymphangioma and Atypical Neurofibroma.

Podoplanin Protein (5)

    Podoplanin Antibody (5)

      Podoplanin cDNA Clone (39)

      NM_006474.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010329.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_019358.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Podoplanin Lysate (4)

        Podoplanin の背景知識

        Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.

        Podoplanin の参考文献

        • Kimura, N. et al., 2005,  Pathol Int. 55 (2): 83-86.
        • Ordóñez, N.G., 2006, Adv Anat Pathol. 13 (2): 83-88.
        • Wicki, A. et al., 2007,  Br. J. Cancer. 96 (1): 1-5.
        • Fujii,T. et al., 2008, Mod Pathol. 21 (2): 125-130.
        • Sawa,Y. et al., 2008, Acta Histochem Cytochem. 41 (5):121-126.
        • Kaddu, S. et al., 2009, Am J Dermatopathol.  31 (2): 137-139.

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