PLK1 Proteins, Antibodies, cDNA Clones Research Reagents

PLK1 (Polo Like Kinase 1) is a protein coding gene located on human chromosome 16p12.2. PLK1 is also known as PLK and STPK13. The human PLK1 gene encodes a 68255 Da protein containing 603 amino acids. The PLK1 protein is biasedly expressed in testis, lymph node and other tissues. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. PLK1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PLK2 is an important paralog of PLK1 gene. PLK1 is associated with some diseases, including Gonococcal Keratitis and Brain Glioma.

PLK1 Protein (2)

    PLK1 Antibody (1)

      PLK1 cDNA Clone (30)

      NM_005030.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011121.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      PLK1 Lysate (2)

        PLK1 の背景知識

        Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1 / PLK-1 is ubiquitously expressed. The mRNA and protein expression of PLK1 / PLK-1, -2 and -4 are coordinately regulated during cell cycle progression, but PLK3 levels are independent of the other three family members. PLK1 / PLK-1 is the most well-characterized member of this family and strongly promotes the progression of cells through mitosis. During the various stages of mitosis PLK1 / PLK-1 localizes to the centrosomes, kinetochores and central spindle. PLKs are dysregulated in a variety of human cancers. PLK1 / PLK-1 overexpression correlates with cellular proliferation and poor prognosis. Serine / threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC / C inhibitors, and the regulation of mitotic exit and cytokinesis. It is required for recovery after DNA damage checkpoint and entry into mitosis. PLK1 / PLK-1 is required for kinetochore localization of BUB1B, spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. PLK1 / PLK-1 Phosphorylates BORA, and thereby promotes the degradation of BORA. PLK1 / PLK-1 also contributes to the regulation of AURKA function and phosphorylates SGOL1.

        PLK1 の参考文献

        • Lee KS, et al. (2008) Self-regulated mechanism of Plk1 localization to kinetochores: lessons from the Plk1-PBIP1 interaction. Cell Div. 3: 4.
        • Zhou T, et al. (2003) A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 5 (1): 127-38.
        • Lee M, et al. (2004) Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene. 23 (4): 865-72.

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