PLAGL1 Antibodies, cDNA Clones Research Reagents

PLAGL1 (PLAG1 Like Zinc Finger 1, also known as ZAC; LOT1; ZAC1), located on 6q24.2, is a Protein Coding gene. This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. The gene produces a 50819 Da protein composed of 463 amino acids. PLAGL1 is a zinc-finger nuclear transcription factor, which possesses antiproliferative effects and is frequently epigenetically silenced during tumorigenesis. PLAGL1 promotes cell cycle arrest and apoptosis through multiple pathways. Diseases such as Transient Neonatal Diabetes Mellitus and Neonatal Diabetes Mellitus are associated with PLAGL1.

PLAGL1 Antibody (1)

    PLAGL1 cDNA Clone (15)

    NM_001080951.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    PLAGL1 qPCR Primer (1)

    PLAGL1 の背景知識

    Pleiomorphic adenoma gene-like 1 (PLAGL1, also known as LOT1 and ZAC) is a zinc-finger nuclear transcription factor, which possesses antiproliferative effects and is frequently epigenetically silenced during tumorigenesis. PLAGL1 gene is located on 6q24-25, a chromosomal region that is frequently deleted in various kinds of cancers. Both promoter hyper-methylation and loss of heterozygosity may lead to the down-regulation of PLAGL1 in human somatic cancers. PLAGL1 protein was originally shown to induce cell-cycle arrest and promote apoptosis in several types of human tumors and therefore it was considered a candidate tumor suppressor. The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses.

    PLAGL1 の参考文献

    • Vega-Benedetti AF, et al. (2017) Plagl1: An important player in diverse pathological processes. J Appl Genet 58 (1): 71-78.
    • Li Z, et al. (2014) Both gene deletion and promoter hyper-methylation contribute to the down-regulation of zac/plagl1 gene in gastric adenocarcinomas: A case control study. Clin Res Hepatol Gastroenterol 38 (6): 744-750.
    • Kowalczyk AE, et al. (2015) Altered expression of the plagl1 (zac1/lot1) gene in colorectal cancer: Correlations to the clinicopathological parameters. Int J Oncol 47 (3): 951-962.
    • Godlewski J, et al. (2016) Plagl1 (zac1/lot1) expression in clear cell renal cell carcinoma: Correlations with disease progression and unfavorable prognosis. Anticancer Res 36 (2): 617-624.

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