PKP1 Antibodies, cDNA Clones Research Reagents

PKP1 (Plakophilin 1, also known as B6P; EDSFS), located on 1q32.1, is a Protein Coding gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. The gene produces an 82861 Da protein composed of 747 amino acids. PKP1 is an important plaque component of desmosomes, major intercellular adhesive junctions that act as anchorage points for intermediate filaments. There are at least 2 isoforms of the PKP1 protein: PKP1a with 726 amino acids and PKP1b with 747 amino acids. Diseases such as Ectodermal Dysplasia/Skin Fragility Syndrome and Ectodermal Dysplasia are associated with PKP1.

PKP1 Antibody (1)

    PKP1 cDNA Clone (15)

    BC114571

    クローニングベクター cDNA 製品

    In lentiviral vector

    PKP1 qPCR Primer (1)

    PKP1 の背景知識

    Plakophilin 1 (PKP1) is a member of the arm-repeat (armadillo) and plakophilin gene families and it is an essential component of the desmosomes. Plakophilin 1 (PKP1) belongs to the arm-repeat protein family which is characterized by the presence of a conserved 42-amino-acid motif. Despite individual members of the family containing a similar type of structural domain, they exhibit diverse cellular functions. PKP1 is ubiquitously expressed in human tissues and, depending on the type of cell, found prominently in the karyoplasm and/or in desmosomes. PKP1 is an important plaque component of desmosomes, major intercellular adhesive junctions that act as anchorage points for intermediate filaments. Abnormal expression of PKP1 was observed in various types of cancer.

    PKP1 の参考文献

    • Martin-Padron J, et al. (2020) Correction: Plakophilin 1 enhances myc translation, promoting squamous cell lung cancer. Oncogene 39 (32): 5494.
    • Hofmann I, et al. (2000) Physical characterization of plakophilin 1 reconstituted with and without zinc. Eur J Biochem 267 (14): 4381-4389.
    • Haase D, et al. (2019) Plakophilin 1 is methylated and has a tumor suppressive activity in human lung cancer. Exp Mol Pathol 108 73-79.
    • Giudici AM, et al. (2020) The isolated armadillo-repeat domain of plakophilin 1 is a monomer in solution with a low conformational stability. J Struct Biol 211 (3): 107569.

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