PKLR Proteins, Antibodies, cDNA Clones Research Reagents

PKLR (Pyruvate Kinase L/R) is a protein coding gene located on human chromosome 1q22. PKLR is also known as PK1, PKL, RPK and PKRL. The human PKLR gene encodes a 61830 Da protein containing 574 amino acids. The PKLR protein is biasedly expressed in liver, kidney and other tissues. Among its related pathways are Glucose metabolism and Regulation of beta-cell development. PKLR is related to magnesium ion binding and pyruvate kinase activity. PKM is an important paralog of PKLR gene. PKLR is associated with some diseases, including Pyruvate Kinase Deficiency Of Red Cells and Adenosine Triphosphate, Elevated, Of Erythrocytes.

PKLR Protein (1)

    PKLR Antibody (2)

      PKLR cDNA Clone (15)

      NM_000298.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      PKLR qPCR Primer (1)

      PKLR の背景知識

      Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.

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