PKD2L2 Antibodies, cDNA Clones Research Reagents

PKD2L2 (Polycystin 2 Like 2, Transient Receptor Potential Cation Channel, also known as TRPP5), located on 5q31.2, is a Protein Coding gene. The gene produces a 73790 Da protein composed of 624 amino acids. Pkd2l2 is a novel member of the polycystic kidney disease (PKD) gene family in mammals. Sequence analysis predicted that PKD2L2 has 6 to 8 transmembrane domains, 2 cation channel motifs, and a channel pore calcium sodium motif. In contrast to PKD2, it has no putative EF-hand or coiled-coil domains. Diseases such as Polycystic Kidney Disease and Kidney Disease are associated with PKD2L2.

PKD2L2 Antibody (1)

    PKD2L2 cDNA Clone (13)

    BC044581

    クローニングベクター cDNA 製品

    In lentiviral vector

    PKD2L2 qPCR Primer (1)

    PKD2L2 の背景知識

    A fifth member of the polycystin family, polycystin-L2, is encoded by PKD2L2 in the human and Pkd2l2 in the mouse. Pkd2l2 is a novel member of the polycystic kidney disease (PKD) gene family in mammals and located on chromosome band 5q31. Prominently expressed in testis. Full-length cDNA sequences for both mouse and human polycystin-L2 were obtained from testis cDNA. Sequence analysis predicts that the mouse and human polycystin-L2 proteins consist of 621 and 624 amino acid residues, respectively. Polycystin-L2 has significant homology with polycystins-L and -2, with similarities of 58 and 59%, respectively. Both human and murine polycystin-L2 proteins are predicted to have seven putative transmembrane (TM) domains, and, by comparison with transient receptor potential channels, the six carboxyl-terminal TM domains are likely to constitute an ion channel subunit.

    PKD2L2 の参考文献

    • Veldhuisen B, et al. (1999) Genes homologous to the autosomal dominant polycystic kidney disease genes (pkd1 and pkd2). Eur J Hum Genet 7 (8): 860-872.
    • Guo L, et al. (2000) Identification and characterization of a novel polycystin family member, polycystin-l2, in mouse and human: Sequence, expression, alternative splicing, and chromosomal localization. Genomics 64 (3): 241-251.
    • Chen Y, et al. (2008) Expression of pkd2l2 in testis is implicated in spermatogenesis. Biol Pharm Bull 31 (8): 1496-1500.

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